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Background: Immune checkpoint inhibitors (ICIs) associated with unique autoimmune side effects that differ from traditional cytotoxic chemotherapy. Pharmacists may play an important role in providing key supportive care measures necessary to aid patients and oncologists through immune-related adverse events (irAEs). This study aims to evaluate the impact of a pharmacist-managed irAE

Journal of Oncology Pharmacy Practice 2021;27(3):596-600. /  Le S, Chang B, Pham A, et al.

There is growing interest in using observational data to assess the safety, effectiveness, and cost effectiveness of medical technologies, but operational, technical, and methodological challenges limit its more widespread use. Common data models and federated data networks offer a potential solution to many of these problems. The open-source Observational and Medical

PharmacoEconomics 2021; 39: 275–285. /  Kent S, Burn E, Dawoud D, et al.

Current shortages in COVID-19 vaccine production and distribution have led some experts to suggest untested regimens. Persons who have had COVID-19 are thought to have protective immunity and memory responses for at least 6 months; however, neither recall responses nor ideal vaccine dosing regimens have been studied in those previously infected with

JAMA 2021;325(14):1467-1469. /  Saadat S, Rikhtegaran Tehrani Z,et al.

Background: Several cases of unusual thrombotic events and thrombocytopenia have developed after vaccination with the recombinant adenoviral vector encoding the spike protein antigen of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (ChAdOx1 nCov-19, AstraZeneca). More data were needed on the pathogenesis of this unusual clotting disorder. Methods: We assessed the clinical

N Engl J Med. 2021 Apr 9. Epub ahead of print. /  Greinacher A, Thiele T, Warkentin TE, et al.

To characterize the population pharmacokinetics (popPK) of ribociclib and population pharmacokinetic/pharmacodynamic (PK/PD) relationship between ribociclib and absolute neutrophil count (ANC) were characterized in patients with cancer. PopPK and ANC PK/PD modeling were both conducted in 2 rounds per data availability. Initial models were developed based on data sets from early-phase trials

J Clin Pharmacol.2021 Mar 13. Epub ahead of print. /  Lu Y, Yang S, Ho YY, et al.

Background: Few small studies have described hospital-acquired infections (HAIs) during COVID-19. Research question: What patient characteristics in critically ill patients with COVID-19 are associated with HAIs and how do HAIs associate with outcomes in these patients? Study design and methods: Multicenter retrospective analysis of prospectively collected data including adult patients with severe

Chest 2021; S0012-3692(21)00679-6. /  Grasselli G, Scaravilli V, Mangioni D, et al.

Background: Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use of monoclonal antibodies. We aimed to describe the emergence of the B.1.1.7 variant of concern (VOC), including virological characteristics and clinical severity in contemporaneous patients

Lancet Infect Dis. 2021:S1473-3099(21)00170-5. /  Frampton D, Rampling T, Cross A,et al.

Importance: Recently, the benefit of adding daratumumab to the proteasome inhibitor-based, 3-drug combination of bortezomib, lenalidomide, and dexamethasone for patients with newly diagnosed multiple myeloma who underwent high-dose melphalan chemotherapy and autologous hemopoietic cell transplant was assessed. Here, we examine the addition of daratumumab to the second-generation proteasome inhibitor-based, 3-drug

JAMA Oncol. 2021 Apr 15. Epub ahead of print. /  Landgren O, Hultcrantz M, Diamond B, et al.

Background:In addition to increased availability of treatment modalities, advanced imaging modalities are increasingly recommended to improve global cancer care. However, estimates of the costs and benefits of investments to improve cancer survival are scarce, especially for low-income and middle-income countries (LMICs). In this analysis, we aimed to estimate the costs

The Lancet Oncology 2021; 22(3):341-350. /  Ward ZJ et al.

Background: The International Society of Oncology Pharmacy Practitioners (ISOPP) is committed to providing educational resources to members for their continuous learning and professional development. This survey was conducted to explore the educational needs of International Society of Oncology Pharmacy Practitioners members for the purpose of developing resources to support future learning

Journal of Oncology Pharmacy Practice 2021;27(3):623-634.. /  Patel H, tan CJ, Toh GL et al.